why pyrazine is weakest base than pyridine?

asked by @kwnstadinav1 • 6 months ago • Organic Chemistry • 5 pts
  • Pyrazine has a greater electron withdrawing region (2nd Nitrogen) compared to pyridine, which causes pyrazine to be more deactivated than pyridine towards nucleophilic attack. Nika commented 6 months ago
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Hi there! I might not discuss all the factors affecting their basicity but here's a major effect that contributes to their basicity, as we can see, pyrazine has 2 N in the ring that will withdraw the electron density to them. This will make a not-so-good proton acceptor therefore a pyridine will appear as a greater base than pyrazine. Hope that helps!

answered by @reynr2 • 6 months ago