Concept #1: Reabsorption in the Proximal Tubule
Concept #2: Mechanism of Bicarbonate Reabsorption
Concept #3: Secretion in the Proximal Tubule
Practice: Sodium-Glucose Linked Transporter (SGLT) Inhibitors are a class of drugs that, by blocking the activity of SGLTs, decrease the reabsorption of glucose and sodium in the proximal tubule. Which of the following is the expected effect of SGLT inhibitors on the volume of fluid present at the end of the proximal tubule (relative to the volume present in an untreated nephron)?
Practice: Hydrochlorothiazide (HCTZ) is a carbonic anhydrase inhibitor. On which membrane of proximal tubule cells does HCTZ act?