We're being asked to rank the reactivity of the given compounds to nucleophilic acyl substitution.
Recall that the reactivity of carbonyls towards nucleophilic acyl substitution depends on the strength of the leaving group.
Rank the following carbonyl-containing compounds in order to reactivity towards nucleophilic acyl substitution.
Butyl acetate, acetic propionic anhydride, 3-methylpentanoyl chloride, propionamide
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What scientific concept do you need to know in order to solve this problem?
Our tutors have indicated that to solve this problem you will need to apply the Nucleophilic Acyl Substitution Reactivity concept. If you need more Nucleophilic Acyl Substitution Reactivity practice, you can also practice Nucleophilic Acyl Substitution Reactivity practice problems.
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Based on our data, we think this problem is relevant for Professor Houck's class at PSU.