We’re being asked to determine the stereochemical configuration of the following molecules.
Recall that the R/S configuration gives us the absolute stereochemistry of chiral centers. It involves:
Step 1: Determine the priority of groups at the chiral center.
• Priority is determined using atomic mass.
• If the same atom is present, we compare the other atoms it is bonded to.
– Double and triple bonds count twice/thrice.
Step 2: Determine the R/S configuration of the chiral center.
• If the lowest priority is on a dashed line: trace a path from 1 to 3
– If the order is clockwise → R (rectus or right)
– If the order is counterclockwise → S (sinister or left)
• If the lowest priority is not on a dashed line: swap with the group on a dashed line
– Trace a path from 1 to 3:
– Clockwise → R becomes S because of the swap
– Counterclockwise → S becomes R because of the swap
Indicate the stereochemical configuration for the tetrahedral centers shown below.
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