Problem: The change is free energy on flipping from a cyclohexane conformer with the indicated substituent equatorial to the conformer with the substituent axial is indicated in the table below:  For each of the following cyclohexane derivatives draw the molecule in the most stable conformation. Be sure to show hydrogen atoms on the substituted ring carbons.

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The change is free energy on flipping from a cyclohexane conformer with the indicated substituent equatorial to the conformer with the substituent axial is indicated in the table below: 

For each of the following cyclohexane derivatives draw the molecule in the most stable conformation. Be sure to show hydrogen atoms on the substituted ring carbons.

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What scientific concept do you need to know in order to solve this problem?

Our tutors have indicated that to solve this problem you will need to apply the Equatorial Preference concept. You can view video lessons to learn Equatorial Preference. Or if you need more Equatorial Preference practice, you can also practice Equatorial Preference practice problems.

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Based on our data, we think this problem is relevant for Professor Runquist's class at SFSU.