Ch. 5 - ChiralityWorksheetSee all chapters
All Chapters
Ch. 1 - A Review of General Chemistry
Ch. 2 - Molecular Representations
Ch. 3 - Acids and Bases
Ch. 4 - Alkanes and Cycloalkanes
Ch. 5 - Chirality
Ch. 6 - Thermodynamics and Kinetics
Ch. 7 - Substitution Reactions
Ch. 8 - Elimination Reactions
Ch. 9 - Alkenes and Alkynes
Ch. 10 - Addition Reactions
Ch. 11 - Radical Reactions
Ch. 12 - Alcohols, Ethers, Epoxides and Thiols
Ch. 13 - Alcohols and Carbonyl Compounds
Ch. 14 - Synthetic Techniques
Ch. 15 - Analytical Techniques: IR, NMR, Mass Spect
Ch. 16 - Conjugated Systems
Ch. 17 - Aromaticity
Ch. 18 - Reactions of Aromatics: EAS and Beyond
Ch. 19 - Aldehydes and Ketones: Nucleophilic Addition
Ch. 20 - Carboxylic Acid Derivatives: NAS
Ch. 21 - Enolate Chemistry: Reactions at the Alpha-Carbon
Ch. 22 - Condensation Chemistry
Ch. 23 - Amines
Ch. 24 - Carbohydrates
Ch. 25 - Phenols
Ch. 26 - Amino Acids, Peptides, and Proteins

Solution: Diseases caused by waterborne parasites constitute a major global health problem. In particular, parasitic diseases affect the world's poorest populations and represent a huge barrier to improving human health and well-being. This year's Nobel Laureates have developed therapies that have revolutionized the treatment of some of the most devastating parasitic diseases. William C. Campbell and Satoshi Ōmura discovered a new drug, Avermectin, the derivatives of which have radically lowered the incidence of River Blindness and Lymphatic Filariasis, as well as showing efficacy against an expanding number of other parasitic diseases.   a. Circle all the chiral centers in  avermectin below.  b. How many chiral centers did you find? ______ c. Based on the chiral centers found, how many stereoisomers are POSSIBLE for   avermectin? ______  

Problem

Diseases caused by waterborne parasites constitute a major global health problem. In particular, parasitic diseases affect the world's poorest populations and represent a huge barrier to improving human health and well-being. This year's Nobel Laureates have developed therapies that have revolutionized the treatment of some of the most devastating parasitic diseases. William C. Campbell and Satoshi Ōmura discovered a new drug, Avermectin, the derivatives of which have radically lowered the incidence of River Blindness and Lymphatic Filariasis, as well as showing efficacy against an expanding number of other parasitic diseases.

 

a. Circle all the chiral centers in  avermectin below. 

b. How many chiral centers did you find? ______

c. Based on the chiral centers found, how many stereoisomers are POSSIBLE for   avermectin? ______