Problem: Determine the index of hydrogen deficiency (degrees of unsaturation) for the following molecule.Antipsychotic - Haloperidol = C21H23NO2ClF

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We’re being asked to determine the index of hydrogen deficiency (IHD) for haloperidol, C21H23NO2ClF.

Recall that the degrees of unsaturation or index of hydrogen deficiency (IHD) tell us how many hydrogens are missing in a structure.

For a given molecular formula, the IHD is calculated using:


where n = number of carbons and H is:

+1 for hydrogen (H) or halogens (X)

0 for oxygen (O)

–1 for nitrogen (N)

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Problem Details

Determine the index of hydrogen deficiency (degrees of unsaturation) for the following molecule.

Antipsychotic - Haloperidol = C21H23NO2ClF

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Our tutors have indicated that to solve this problem you will need to apply the Degrees of Unsaturation concept. You can view video lessons to learn Degrees of Unsaturation. Or if you need more Degrees of Unsaturation practice, you can also practice Degrees of Unsaturation practice problems.

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