Williamson ether synthesis → production of ether from alkoxide + 1° alkyl halide
Alkene + H2SO4 → acid-catalyzed hydration (follows Markonivkov rule)
Alkene + HBr/ROOR → radical halogenation (follows anti-Markonivkov rule)
The most common method for the synthesis of unsymmetrical ethers is the Williamson synthesis, a reaction (SN2) of an alkoxide ion with an alkyl halide. Two pathways are possible, but often one is preferred. Construct the preferred pathway for the synthesis of 2-propoxypropane from propene, with propene-derived alkyl halide and alkoxide intermediates, by dragging the appropriate intermediates and reagents into their bins. Not every given reagent or intermediate will be used.
Frequently Asked Questions
What scientific concept do you need to know in order to solve this problem?
Our tutors have indicated that to solve this problem you will need to apply the Williamson Ether Retrosynthesis concept. If you need more Williamson Ether Retrosynthesis practice, you can also practice Williamson Ether Retrosynthesis practice problems.