EAS: Retrosynthesis Video Lessons

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Problem: Complete the synthesis below by selecting or drawing the reagents.Reagent A:a) Br2, FeBr3b) Mg, THFc) Mg, Br2Reagent B:a) Mg, THFb) HBrc) Br2, FeBr3Reagent C:a) PCCb) H3O+ c) KMnO4

FREE Expert Solution

Recall that:

  1. Bromination of Benzene
    • Reagents: Br2,FeBr3
  2. Preparation of Grignard Reagents (RMgX)
    • Reagents: Mg, Cyclic ether (e.g. THF)
  3. Full Oxidation: ROH → RCOOH
    • Reagent: KMnO4
      • PCC only oxidizes 1° OH to Aldehydes
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Problem Details

Complete the synthesis below by selecting or drawing the reagents.

Reagent A:

a) Br2, FeBr3

b) Mg, THF

c) Mg, Br2

Reagent B:

a) Mg, THF

b) HBr

c) Br2, FeBr3

Reagent C:

a) PCC

b) H3O+ 

c) KMnO4

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