Given reaction: Addition of a methyl group at the end → possible via alkynides
Possible sequence of reactions:
1. Halogenation → form vicinal dihalides (Br2)
2. Double elimination + deprotonation → form alkyne then alkynide (excess NaNH2)
In each reaction box, place the best reagent and conditions from the list below
Br2 excess NaNH2 PBr3 2 equiv. NaNH2 NaBH4 CH3CH2Br H2, Lindlar catalyst CH3Br Na, NH3 (l) HBr BH3/THF H20, H2SO4, HgSO4 H2O2, NaOH, H20
Frequently Asked Questions
What scientific concept do you need to know in order to solve this problem?
Our tutors have indicated that to solve this problem you will need to apply the Addition Retrosynthesis concept. If you need more Addition Retrosynthesis practice, you can also practice Addition Retrosynthesis practice problems.