Problem: Asparagine is a polar amino acid, shown here at pH 7.What is the maximum number of water molecules that, in theory, one asparagine molecule at pH 7 could hydrogen bond with?(Consider any intermolecular attractions between the asparagine molecule and water to be hydrogen bonds.)

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  • Hydrogen bonds occurs to Hs attached to an electronegative atom (N, O or F) 
  • Structure appears to have 1 N with 1 lone pair, 2 Os with 2 lone pairs and 1 O with 3 lone pairs
  • Each lone pair is capable of accepting 1 H-bonds; hence it can accept 8 H bonds
  • For the Hs attached to N or O; the total of number of Hs is 5 Hs
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Problem Details

Asparagine is a polar amino acid, shown here at pH 7.

What is the maximum number of water molecules that, in theory, one asparagine molecule at pH 7 could hydrogen bond with?

(Consider any intermolecular attractions between the asparagine molecule and water to be hydrogen bonds.)


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