We are asked to draw the major product of the following three-step synthesis.
We can see that we have a ketone and an amine with acid in the very first step. This means we are going to work with Enamines.
The Michael Reaction/Addition is a 1,4-conjugate addition of an enone with an enolate and always forms 1,5-dicarbonyls.
The mechanism steps are listed below:
Draw the major product of the following three-step synthesis.
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What scientific concept do you need to know in order to solve this problem?
Our tutors have indicated that to solve this problem you will need to apply the Michael Addition concept. You can view video lessons to learn Michael Addition. Or if you need more Michael Addition practice, you can also practice Michael Addition practice problems.
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