For this problem, we have to predict the minor and major products of iodination of salicylamide
Iodination is an EAS reaction where the substitution depends on the substituents pre-attached on the ring. We need to follow these steps:
Step 1. Highlight the substituent and categorize them if o,p or meta director
Step 2. Determine the o, p and meta positions for the substituents
Step 3. Draw all the possible products
Step 4. Determine the major product
Step 1. In this case, we have an -OH and a -CONH2 (amide group):
Consider the directing effects of the substituents on salicylamide and predict the possible structures of the iodination products. Which do you think will be the major products? Explain your reasoning.
Frequently Asked Questions
What scientific concept do you need to know in order to solve this problem?
Our tutors have indicated that to solve this problem you will need to apply the EAS: Ortho vs. Para Positions concept. You can view video lessons to learn EAS: Ortho vs. Para Positions. Or if you need more EAS: Ortho vs. Para Positions practice, you can also practice EAS: Ortho vs. Para Positions practice problems.
What is the difficulty of this problem?
Our tutors rated the difficulty ofConsider the directing effects of the substituents on salicy...as medium difficulty.
What professor is this problem relevant for?
Based on our data, we think this problem is relevant for Professor Santander's class at TAMU.