For this problem, we have to predict the minor and major products of iodination of salicylamide
Iodination is an EAS reaction where the substitution depends on the substituents pre-attached on the ring. We need to follow these steps:
Step 1. Highlight the substituent and categorize them if o,p or meta director
Step 2. Determine the o, p and meta positions for the substituents
Step 3. Draw all the possible products
Step 4. Determine the major product
Step 1. In this case, we have an -OH and a -CONH2 (amide group):
Consider the directing effects of the substituents on salicylamide and predict the possible structures of the iodination products. Which do you think will be the major products? Explain your reasoning.