Problem: Consider the directing effects of the substituents on salicylamide and predict the possible structures of the iodination products. Which do you think will be the major products? Explain your reasoning.

FREE Expert Solution

For this problem, we have to predict the minor and major products of iodination of salicylamide

Iodination is an EAS reaction where the substitution depends on the substituents pre-attached on the ring. We need to follow these steps:

Step 1. Highlight the substituent and categorize them if o,p or meta director

Step 2. Determine the o, p and meta positions for the substituents

Step 3. Draw all the possible products

Step 4. Determine the major product



Step 1. In this case, we have an -OH and a -CONH(amide group):

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Problem Details

Consider the directing effects of the substituents on salicylamide and predict the possible structures of the iodination products. Which do you think will be the major products? Explain your reasoning.