Problem: The imidazole ring system, which contains two nitrogen atoms, is found in the amino acid histidine. Which statement is true regarding the basicity of the two ring nitrogen atoms? A) Both are strongly basic since the ring is aromatic. B) The nitrogen atom labeled (1) is more basic than (2). C) The nitrogen atom labeled (2) is more basic than (1). D) Neither of the nitrogen atoms would be considered basic.

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The imidazole ring system, which contains two nitrogen atoms, is found in the amino acid histidine. Which statement is true regarding the basicity of the two ring nitrogen atoms?

A) Both are strongly basic since the ring is aromatic.

B) The nitrogen atom labeled (1) is more basic than (2).

C) The nitrogen atom labeled (2) is more basic than (1).

D) Neither of the nitrogen atoms would be considered basic.

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Based on our data, we think this problem is relevant for Professor Paige's class at GMU.