It's time to learn about The 3 Rules for Nucleophilic Acyl Substitution. Are you ready?
Concept #1: NAS - The Three Rules
RULE 1: General Reactions
RULE 2: More reactive acyl compounds can be easily converted into less reactive ones.
RULE 3: Carboxylic Acid Conversions
Practice: Determine the major product for the following reaction.
Practice: Determine the major product for the following reaction.
Practice: Determine the major product for the following reaction.
Practice: Determine the major product for the following reaction.