Ch. 21 - Enolate Chemistry: Reactions at the Alpha-Carbon WorksheetSee all chapters
All Chapters
Ch. 1 - A Review of General Chemistry
Ch. 2 - Molecular Representations
Ch. 3 - Acids and Bases
Ch. 4 - Alkanes and Cycloalkanes
Ch. 5 - Chirality
Ch. 6 - Thermodynamics and Kinetics
Ch. 7 - Substitution Reactions
Ch. 8 - Elimination Reactions
Ch. 9 - Alkenes and Alkynes
Ch. 10 - Addition Reactions
Ch. 11 - Radical Reactions
Ch. 12 - Alcohols, Ethers, Epoxides and Thiols
Ch. 13 - Alcohols and Carbonyl Compounds
Ch. 14 - Synthetic Techniques
Ch. 15 - Analytical Techniques: IR, NMR, Mass Spect
Ch. 16 - Conjugated Systems
Ch. 17 - Aromaticity
Ch. 18 - Reactions of Aromatics: EAS and Beyond
Ch. 19 - Aldehydes and Ketones: Nucleophilic Addition
Ch. 20 - Carboxylic Acid Derivatives: NAS
Ch. 21 - Enolate Chemistry: Reactions at the Alpha-Carbon
Ch. 22 - Condensation Chemistry
Ch. 23 - Amines
Ch. 24 - Carbohydrates
Ch. 25 - Phenols
Ch. 26 - Amino Acids, Peptides, and Proteins

Concept #1: General Reaction

Concept #2: Directed Reactions

Concept #3: Enolates of Esters

Practice: Determine if the reaction is thermodynamically or kinetically controlled

Additional Problems
Predict the product of the following reaction. 
What would be the major product of the following reaction sequence? a I b II c III d IV e V
Predict the major product for the following reaction, paying attention to the regio- and stereochemistry where appropriate. 
Which electrophile will give the best enolate alkylation?
What would be the major product of the following reaction sequence?
What is the principal product of the following reaction?
What is the product of the following reaction?
What is the product of the following reaction?
What is the product of the following reaction?
Predict the product(s) for each of the following reaction. When appropriate, labelthem major and minor.
What would be the major product of the following reaction sequence?A) IB) IIC) IIID) IVE) V
Predict the product(s) for the following reaction. When appropriate, label them major and minor. 
Which of the following products results from the reaction shown?
Predict the major organic product of the following transformation.
Draw the major organic for the following two-step reaction?Which enolate anion is formed? Kinetic thermodynamic
Draw the major organic for the following two-step reaction: Which enolate anion is formed?
Draw the major product for the following two-step reaction:
Draw the structure(s) of the major organic product(s) of the following reaction. • You do not have to consider stereochemistry. • Omit products derived from the acidic or basic reagent itself, e.g. HN(i-Pr)2 derived from N(i-Pr)2. • If no reaction occurs, draw the organic starting material.• If substantial starting material is present at the end of the reaction, include it in the products. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner. . • Separate structures with + signs from the drop-down menu opy aste