Enolate Alkylation and Acylation

Concept: Concept: General Reaction

Video Transcript

In this video, I want to discuss enolate alkylations and acylations. There's really nothing tricky to this reaction. As long as you can draw an enolate, you can do an enolate alkylation because all it is is that you’re either exposing an enolate to an alkyl halide or you're exposing an enolate to an acid chloride. What happens is the base grabs one of the protons and the alpha-carbon. You make a negatively charged enolate. That does a nucleophilic attack on either alkyl halide or on the acid chloride. If you use an alkyl halide, then this would be my product, an alpha-alyklated carbon. If you use your acid chloride, then you're going to wind up getting an acylated carbon, so you’d get a beta-dicarbonyl with an R group.
That’s it guys. This is a very easy mechanism to understand, very easy reaction to understand. So, let’s move on to the next part of the page. 

Problem: Determine if the reaction is thermodynamically or kinetically controlled