Concept: Concept: Proposing Aromatic Synthesis1m
Now we're going to get some practice proposing aromatic synthesis specifically diazo replacement reactions.
So as you guys know, a big part of this topic is being able to turn a smaller benzene into a bigger one. We must use our knowledge of sequence groups and blocking groups to plan out our synthesis in the correct order.
So guys, you should have already had some practice with this at this point. So I'm going to leave these up to you completely. Go ahead and try to do this one from scratch with everything you know about diazo and then I'll step in and show you guys the answer. So go for it.
Concept: Example 1: Synthesize the target molecule5m
Concept: Example 2: Synthesize the target molecule8m
Show how you would accomplish the following coversion.
Draw the reactant of the following reaction. Indicate stereochemistry where appropriate.
Draw the organic product(s) for the following reaction. Indicate stereochemistry where appropriate. Assume an aqueous workup, when necessary. A reasonable answer may be “ No Reaction.”
Devise an efficient synthesis of the following compound using benzene as your only hydrocarbon starting material. Any other reagents used should have three or fewer carbon atoms. Note: A reaction mechanism (i.e.; arrow-pushing) is not required.