Concept: Practice: Intro to Predict the Product1m
Now we're going to do some predict the product practice problems involving all the different reactions that organometallics can undergo. Keep in mind that some of these reactions, will be multiple step reactions. So what that means is that you may have to draw back from previous lessons in order to really figure out the entire thing.
At the end, just like always, I'll explain the answers to every problem. Let's go ahead and begin with problem one.
Concept: Practice: Intro to Retrosynthesis1m
Now let's focus on some practice problems involving organometallics, but going the other way around. We want to do some retro-synthesis now. What that means is you're going to try to figure out what reagents it's going to take to make the final product. Think about all of the different reactions of organometallics we talked about and see how you can use them to your advantage in the next few questions.
Let's go ahead and try to do the first one.
Problem: Propose a synthesis to accomplish the following transformation5m
Problem: Propose a synthesis to accomplish the following transformation7m
Problem: Predict the product of the reaction8m
Predict the missing structures of products or reagents that you may use to accomplish the following transformations. Show the source of incorporation of deuterium and the stereochemistry when appropriate (No mechanism is required).
Please provide regents, conditions, and desired products in the blank boxes for the synthetic scheme below.
Provide the reagents necessary for the following conversion.
a) 1. CH3CH2MgBr/ether, 2. H3O+, Δ
b) 1. NaBH4/CH3OH, 2. CH3CH2MgBr
c) 1. H3O+ , CH3CH2MgBr/ether
Draw the major organic product or reactant in the boxes provided for each reaction. Aqueous work up assumed where necessary.