Ch. 26 - Transition MetalsWorksheetSee all chapters
All Chapters
Ch. 1 - A Review of General Chemistry
Ch. 2 - Molecular Representations
Ch. 3 - Acids and Bases
Ch. 4 - Alkanes and Cycloalkanes
Ch. 5 - Chirality
Ch. 6 - Thermodynamics and Kinetics
Ch. 7 - Substitution Reactions
Ch. 8 - Elimination Reactions
Ch. 9 - Alkenes and Alkynes
Ch. 10 - Addition Reactions
Ch. 11 - Radical Reactions
Ch. 12 - Alcohols, Ethers, Epoxides and Thiols
Ch. 13 - Alcohols and Carbonyl Compounds
Ch. 14 - Synthetic Techniques
Ch. 15 - Analytical Techniques: IR, NMR, Mass Spect
Ch. 16 - Conjugated Systems
Ch. 17 - Aromaticity
Ch. 18 - Reactions of Aromatics: EAS and Beyond
Ch. 19 - Aldehydes and Ketones: Nucleophilic Addition
Ch. 20 - Carboxylic Acid Derivatives: NAS
Ch. 21 - Enolate Chemistry: Reactions at the Alpha-Carbon
Ch. 22 - Condensation Chemistry
Ch. 23 - Amines
Ch. 24 - Carbohydrates
Ch. 25 - Phenols
Ch. 26 - Amino Acids, Peptides, and Proteins
Ch. 26 - Transition Metals
Sections
Electron Configuration of Elements
Coordination Complexes
Ligands
Electron Counting
The 18 and 16 Electron Rule
Cross-Coupling General Reactions
Heck Reaction
Stille Reaction
Suzuki Reaction
Sonogashira Coupling Reaction
Fukuyama Coupling Reaction
Kumada Coupling Reaction
Negishi Coupling Reaction
Buchwald-Hartwig Amination Reaction
Eglinton Reaction

Concept #1: Overview of Cross-Coupling General Reactions

Concept #2: Coupling Agent

Example #1: The Heck reaction is a well-known coupling reaction that involves the combining of a carbon halide with an alkene. Base on the example provided determine a possible coupling product.

Practice: In the Stille reaction, an organostannane compound reacts with a carbon halide in order to form a new carbon-carbon bond. What would be the final product from the following Stille coupling reaction?

Concept #3: Cross-Coupling Reaction Mechanisms

Example #2: Determine the new palladium complex that forms during this oxidative addition step. 

Practice: Determine the new cadmium complex that forms during this oxidative addition step. 

Concept #4: Transmetallation

Example #3: Determine the product(s) formed in the following reaction sequence.

Concept #5: Reductive Elimination

Example #4: Determine the final product in the following reaction. 

Concept #6: Mechanism Cycle