Ch. 5 - ChiralitySee all chapters
All Chapters
Ch. 1 - A Review of General Chemistry
Ch. 2 - Molecular Representations
Ch. 3 - Acids and Bases
Ch. 4 - Alkanes and Cycloalkanes
Ch. 5 - Chirality
Ch. 6 - Thermodynamics and Kinetics
Ch. 7 - Substitution Reactions
Ch. 8 - Elimination Reactions
Ch. 9 - Alkenes and Alkynes
Ch. 10 - Addition Reactions
Ch. 11 - Radical Reactions
Ch. 12 - Alcohols, Ethers, Epoxides and Thiols
Ch. 13 - Alcohols and Carbonyl Compounds
Ch. 14 - Synthetic Techniques
Ch. 15 - Analytical Techniques: IR, NMR, Mass Spect
Ch. 16 - Conjugated Systems
Ch. 17 - Aromaticity
Ch. 18 - Reactions of Aromatics: EAS and Beyond
Ch. 19 - Aldehydes and Ketones: Nucleophilic Addition
Ch. 20 - Carboxylic Acid Derivatives: NAS
Ch. 21 - Enolate Chemistry: Reactions at the Alpha-Carbon
Ch. 22 - Condensation Chemistry
Ch. 23 - Amines
Ch. 24 - Carbohydrates
Ch. 25 - Phenols
Ch. 26 - Amino Acids, Peptides, and Proteins

The gold standard chirality test for almost all molecules involves finding stereocenters.

Defining Stereocenters

Any atom that creates a stereoisomer after swapping two groups is called a stereocenter.

Concept #1: What is a stereocenter?

Types of Stereocenters

Concept #2: The difference between chiral and trigonal centers.

Does the following molecule contain a stereogenic center? Is it chiral?

Example #1: Does the following molecule contain a stereogenic center? Is it chiral?

Does the following molecule contain a stereogenic center? Is it chiral?​

Example #2: Does the following molecule contain a stereogenic center? Is it chiral?

Does the following molecule contain a stereogenic center? Is it chiral?

Example #3: Does the following molecule contain a stereogenic center? Is it chiral?

Does the following molecule contain a stereogenic center? Is it chiral?

Example #4: Does the following molecule contain a stereogenic center? Is it chiral?

Does the following molecule contain a stereogenic center? Is it chiral?

Example #5: Does the following molecule contain a stereogenic center? Is it chiral?

 

Does the following molecule contain a stereogenic center? Is it chiral?

Example #6: Does the following molecule contain a stereogenic center? Is it chiral?

Additional Problems
Anti - nausea medication Zofran is often used for severe nausea as a result of chemotherapy, radiation, surgery, and gastroenteritis. By the final year of its patent (2006), GlaxoSmithKline's Zofran had become the 20th highest selling brand-name drug in the United States, with sales of US $1.3 billion in the first 9 months of 2006. Phenobarbital is a barbiturate, nonselective central nervous system depressant which is primarily used as a sedative hypnotic and also as an anticonvulsant. This medication is particulary helpful in managing terminal restlessness. Place a star/asterisk next to all the stereocenters in these two molecules. 
Which of the numbered carbon atoms in this compound are stereocenters? a) 1, 2, 3 b) 1, 3 only c) 2 only d) 2, 3 only
How many stereocenters (chiral centers) are present in this molecule? a. 4  b. 3 c. 2 d. 1
Locate all steroecenter(s) in each structure below. 
Circle the chiral centers of the following molecule:
How many stereocenters are there in the sugar, shown below? a) 2 b) 3 c) 4 d) 5
Provide an example of a chiral hydrocarbon with 6 carbons.
How many chirality centers are there in the following molecule?A. oneB. twoC. threeD. fourE. fiveF. six
Consider the structures below. Circle all structures that are chiral.
Label the following molecule as either chiral or not chiral.
Label the following molecule as either chiral or not chiral.
Label with an asterisk (*) all of the chirality centers in a molecule of the antibiotic amoxicillin. On the provided line, write the number of stereoisomers that are possible for a molecule with that many chirality centers.
Determine which structure has more chiral centers, A or B. In the event that they have the same number of chiral center's, write 'Neither'. 
What is the minimum number of carbons necessary to arrive at a chiral acyclic difluoroalkane composed solely of sp3 hybridized carbon atom? Remember, a molecule is chiral if it is not superimposable upon its mirror image. 
How many chirality center(s) is (are) present in the following compound (TamifluⓇ)?
Identify whether each of the following compounds is chiral or achiral:
 Identify whether each of the following compounds is chiral or achiral:
 Identify whether each of the following compounds is chiral or achiral:
 Identify whether each of the following compounds is chiral or achiral:
Which of the following molecules contain a stereogenic center? Of these, how many are chiral?
Locate all chirality centers in the following compound
Identify all the chiral centers in the following compound
Indicate if the compounds are chiral or achiral. 
Which compounds contain stereocentres? Select one: a. I, II b. I, III c. III, IV d. II, IV 
How many stereocenters are present in each compound?