Ch. 20 - Carboxylic Acid Derivatives: NAS WorksheetSee all chapters
All Chapters
Ch. 1 - A Review of General Chemistry
Ch. 2 - Molecular Representations
Ch. 3 - Acids and Bases
Ch. 4 - Alkanes and Cycloalkanes
Ch. 5 - Chirality
Ch. 6 - Thermodynamics and Kinetics
Ch. 7 - Substitution Reactions
Ch. 8 - Elimination Reactions
Ch. 9 - Alkenes and Alkynes
Ch. 10 - Addition Reactions
Ch. 11 - Radical Reactions
Ch. 12 - Alcohols, Ethers, Epoxides and Thiols
Ch. 13 - Alcohols and Carbonyl Compounds
Ch. 14 - Synthetic Techniques
Ch. 15 - Analytical Techniques: IR, NMR, Mass Spect
Ch. 16 - Conjugated Systems
Ch. 17 - Aromaticity
Ch. 18 - Reactions of Aromatics: EAS and Beyond
Ch. 19 - Aldehydes and Ketones: Nucleophilic Addition
Ch. 20 - Carboxylic Acid Derivatives: NAS
Ch. 21 - Enolate Chemistry: Reactions at the Alpha-Carbon
Ch. 22 - Condensation Chemistry
Ch. 23 - Amines
Ch. 24 - Carbohydrates
Ch. 25 - Phenols
Ch. 26 - Amino Acids, Peptides, and Proteins

Let's learn a really cool way to make carboxylic acids! Are you ready?

Concept #1: Carbonation of Grignard Reagents

Practice: Determine the major product for the following reaction. 

Additional Problems
Besides attacking carbonyl groups, Grignard Reagents can react with other functional groups. Give the product for the following reaction.
Determine the reagent(s) necessary for the reaction below.  
Determine the reagent(s) necessary for the reaction below.
Determine the reagent(s) necessary for the reaction below.
The following reaction below will proceed in yielding a _________ in place of the starting substituent on the product. A) Carboxylic Acid B) Amine C) Carbonyl D) Nitriles E) Aldehydes
Propose a sequence of organic reactions, including the necessary reagents, to achieve the following conversion.
Determine the product for the reaction below.
Complete the following reaction supplying the missing reactant, product or reagent.
Give the appropriate reagent to achieve the indicated one-step transformation.
Give the appropriate reagent to achieve the indicated multi-step retrosynthesis.
Device a synthetic pathway to form each of the following products
Predict the product(s) for each of the following reactions. When appropriate, Iabel them major and minor.
What product is formed from this reaction sequence?
Provide a detailed mechanism for the carboxylation below. 
Predict the product for the following reaction sequence.a. 2, 2-dlmethylpropanolc acid b.3, 3-dimethyl-2-butanone c. 2, 2-dimethyl-l-propanol d. 2, 2-dlmethylbutanoic acid e. none of these
Consider the reaction below between between CO2 and CH3MgCI. For the sake of simplicity, the +MgCI counterion has been omitted. Draw the curved arrows depicting the reaction between CO2 and CH3MgCI.Draw the organic synthetic intermediate, including all lone-pair electrons and charges. Draw the final organic product, including all lone-pair electrons and charges after aqueous acid workup.