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Problem: Huntington's disease is an inherited autosomal dominant disorder that can affect both men and women. Imagine a couple has had seven children, and later in life, the husband develops Huntington's disease. He is tested and it is discovered he is heterozygous for the disease allele, Hh. The wife is also genetically tested for the Huntington's disease allele, and her test results show she is unaffected, hh. What is the percent probability that the first child of this couple will have Huntington's disease?also.What is the probability that any two of the seven children will have Huntington's disease?

FREE Expert Solution

Huntington's Disease = autosomal dominant

Parent Generation: Hh × hh


Test Cross:

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Problem Details

Huntington's disease is an inherited autosomal dominant disorder that can affect both men and women. Imagine a couple has had seven children, and later in life, the husband develops Huntington's disease. He is tested and it is discovered he is heterozygous for the disease allele, Hh. The wife is also genetically tested for the Huntington's disease allele, and her test results show she is unaffected, hh. What is the percent probability that the first child of this couple will have Huntington's disease?also.

What is the probability that any two of the seven children will have Huntington's disease?

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Based on our data, we think this problem is relevant for Professor Casselman's class at UAB.