Telomeres and Telomerase Video Lessons

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Problem: Order the events in which telomerase maintains chromosomal ends during replication. Not all events will be used:Synthesis occurs on the 5' end of the complementary strand of DNA to fill the gap created by telomerase.Synthesis occurs on the 3' end of the complementary strand of DNA to fill the gap created by telomerase.Nucleotides that are complementary to the RNA component of telomerase are added to the 3' end of the DNA.Telomerase moves along the newly synthesized DNA strand toward the 5' end. Telomerase is removed from the DNA strand entirety.Telomerase moves along the newly synthesized DNA strand toward the 3' end.Additional nucleotides are added to the 3' end of the DNA.The RNA component of telomerase binds to a complementary sequence on the 3'-G overhang of DNA.

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Telomerase: enzyme used to maintain chromosome length during replication

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Problem Details

Order the events in which telomerase maintains chromosomal ends during replication. Not all events will be used:

Synthesis occurs on the 5' end of the complementary strand of DNA to fill the gap created by telomerase.

Synthesis occurs on the 3' end of the complementary strand of DNA to fill the gap created by telomerase.

Nucleotides that are complementary to the RNA component of telomerase are added to the 3' end of the DNA.

Telomerase moves along the newly synthesized DNA strand toward the 5' end. 

Telomerase is removed from the DNA strand entirety.

Telomerase moves along the newly synthesized DNA strand toward the 3' end.

Additional nucleotides are added to the 3' end of the DNA.

The RNA component of telomerase binds to a complementary sequence on the 3'-G overhang of DNA.

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Based on our data, we think this problem is relevant for Professor Mattingly's class at KU.