Sequencing the Genome Video Lessons

Video Thumbnail

Concept

Problem: • There are approximately 3,000,000,000 base pairs in the mammalian genome (genes constitute only a small portion of this total).• There are approximately 10,000 genes in the mammalian genome.• A single gene averages about 10,000 base pairs in size.Questions:1. Based on the assumptions above, in the mammalian genome, how many total base pairs are in all the mammalian genes? Show your math.2. What proportion (%) of the total genome does this represent? Show your math.3. What is the probability that a random mutation will occur in any given gene? Show your math.4. Only 1 out of 3 mutations that occur in a gene result in a change to the protein structure. What is the probability that a random mutation will change the structure of a protein? Show your math.

FREE Expert Solution

Given: Mammalian Genome

• 3 × 109 bps

• 1 × 104 genes

• 1 × 104 bp/gene


1. Calculating for the total number of base pairs in mammalian genes:

1×104 genes×1×104 base pairsgene = 1 × 108 base pairs


Answer: There are 1 × 108 base pairs in mammalian genes.

View Complete Written Solution
Problem Details

• There are approximately 3,000,000,000 base pairs in the mammalian genome (genes constitute only a small portion of this total).
• There are approximately 10,000 genes in the mammalian genome.
• A single gene averages about 10,000 base pairs in size.

Questions:
1. Based on the assumptions above, in the mammalian genome, how many total base pairs are in all the mammalian genes? Show your math.
2. What proportion (%) of the total genome does this represent? Show your math.
3. What is the probability that a random mutation will occur in any given gene? Show your math.
4. Only 1 out of 3 mutations that occur in a gene result in a change to the protein structure. What is the probability that a random mutation will change the structure of a protein? Show your math.

Frequently Asked Questions

What scientific concept do you need to know in order to solve this problem?

Our tutors have indicated that to solve this problem you will need to apply the Sequencing the Genome concept. You can view video lessons to learn Sequencing the Genome. Or if you need more Sequencing the Genome practice, you can also practice Sequencing the Genome practice problems.

What professor is this problem relevant for?

Based on our data, we think this problem is relevant for Professor Laybourn's class at CSU.