Comparative Genomics Video Lessons

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Problem: You have constructed four different libraries: a genomic library made from DNA isolated from human brain tissue, a genomic library made from DNA isolated from human muscle tissue, a human brain cDNA library, and a human muscle cDNA library.A) Which of these would have the greatest diversity of sequences?B) Would the sequences contained in each library be expected to overlap completely, partially, or not at all?

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Genomic Information: same regardless of which cell it came from

: DNA library would overlap with the cDNA library

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Problem Details

You have constructed four different libraries: a genomic library made from DNA isolated from human brain tissue, a genomic library made from DNA isolated from human muscle tissue, a human brain cDNA library, and a human muscle cDNA library.

A) Which of these would have the greatest diversity of sequences?

B) Would the sequences contained in each library be expected to overlap completely, partially, or not at all?

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