Types of Mutations Video Lessons

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Problem: The following sequence of DNA is part of the normal, wild-type gene: 5'–ATG CGG GTA GTT AGC CGA TAG–3'. A deletion occurs during DNA replication, causing the guanine shown in bold to be removed from the nucleotide strand. What effect is this most likely to have on the final protein?A. The deletion of the G will cause a frame shift, so that the first amino acid after the mutation will change.B. The deletion of the G will cause a frame shift, resulting in a premature stop codon and a truncated protein.C. The deletion of the G will not have an effect on the final protein.D. The deletion of the G will cause a single amino acid substitution in the codon in which it occurs.E. The deletion of the G will cause a frame shift, resulting in the loss of the normal stop codon and an abnormally long protein with an altered amino acid sequence.

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Problem Details

The following sequence of DNA is part of the normal, wild-type gene: 5'–ATG CGG GTA GTT AGC CGA TAG–3'. A deletion occurs during DNA replication, causing the guanine shown in bold to be removed from the nucleotide strand. What effect is this most likely to have on the final protein?

A. The deletion of the G will cause a frame shift, so that the first amino acid after the mutation will change.

B. The deletion of the G will cause a frame shift, resulting in a premature stop codon and a truncated protein.

C. The deletion of the G will not have an effect on the final protein.

D. The deletion of the G will cause a single amino acid substitution in the codon in which it occurs.

E. The deletion of the G will cause a frame shift, resulting in the loss of the normal stop codon and an abnormally long protein with an altered amino acid sequence.

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