Mutation: changes in the DNA sequence
Which of the following is an example of a mutation?
A. A frog is missing a leg because as an embryo it survived an attack by a predator
B. During transcription, RNA polymerase incorporates a U instead of an A (opposite a T in the DNA template)
C. A phosphate group (-PO4) is added to an amino acid side chain in a polypeptide, which destroys its function
D. An A-T base pair in a gene is changed to a G-C base pair
E. A methyl group (-CH3) is added to a cytosine base in DNA