CML: short for chronic myleoid leukemia; present in individuals with the Philadelphia chromosome (BCR-ABL1 fusion gene)
: the BCR-ABL1 fusion can be transcribed and translated but may not form the protein correctly due to errors in post-translational modifications
Explain how these individuals can carry a fusion gene that is transcriptionally active and yet do not develop CML.
a) CML is actually developing in a latent form.
b) A single gene alteration is not the only requirement for CML.
c) Developing CML after the gene fusion can take a long time.
d) None of the above
Frequently Asked Questions
What scientific concept do you need to know in order to solve this problem?
Our tutors have indicated that to solve this problem you will need to apply the Spontaneous Mutations concept. You can view video lessons to learn Spontaneous Mutations. Or if you need more Spontaneous Mutations practice, you can also practice Spontaneous Mutations practice problems.