Problem: Explain how these individuals can carry a fusion gene that is transcriptionally active and yet do not develop CML.a) CML is actually developing in a latent form.b) A single gene alteration is not the only requirement for CML.c) Developing CML after the gene fusion can take a long time.d) None of the above

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CML: short for chronic myleoid leukemia; present in individuals with the Philadelphia chromosome (BCR-ABL1 fusion gene)

: the BCR-ABL1 fusion can be transcribed and translated but may not form the protein correctly due to errors in post-translational modifications

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Problem Details

Explain how these individuals can carry a fusion gene that is transcriptionally active and yet do not develop CML.

a) CML is actually developing in a latent form.

b) A single gene alteration is not the only requirement for CML.

c) Developing CML after the gene fusion can take a long time.

d) None of the above