CML: short for chronic myleoid leukemia; present in individuals with the Philadelphia chromosome (BCR-ABL1 fusion gene)
: the BCR-ABL1 fusion can be transcribed and translated but may not form the protein correctly due to errors in post-translational modifications
Explain how these individuals can carry a fusion gene that is transcriptionally active and yet do not develop CML.
a) CML is actually developing in a latent form.
b) A single gene alteration is not the only requirement for CML.
c) Developing CML after the gene fusion can take a long time.
d) None of the above