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Problem: If studies in mice hold true for humans, which of the following will be true?a) When given NMN, NAD+ and PARP1 activity will increase.b) When given NMN, NAD+ will increase and PARP1 activity will decrease.c) When given NMN, NAD+ will decrease and PARP1 activity will increase.d) When given NMN, NAD+ and PARP1 activity will decrease.

FREE Expert Solution

PARP1: poly[ADP-ribose] polymerase; class of enzymes that detects DNA damage and determine repair mechanism

: modifies chromatin structure for DNA repair

DBC1: deleted in breast cancer 1; regulates apoptosis, transcription and histone modifications

: usually binds to NAD+

: in the absence of NAD+, DBC1 binds to PARP1, lowering the enzyme activity of PARP1

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Problem Details

If studies in mice hold true for humans, which of the following will be true?

a) When given NMN, NAD+ and PARP1 activity will increase.

b) When given NMN, NAD+ will increase and PARP1 activity will decrease.

c) When given NMN, NAD+ will decrease and PARP1 activity will increase.

d) When given NMN, NAD+ and PARP1 activity will decrease.

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Our tutors have indicated that to solve this problem you will need to apply the DNA Repair concept. You can view video lessons to learn DNA Repair . Or if you need more DNA Repair practice, you can also practice DNA Repair practice problems.