PARP1: poly[ADP-ribose] polymerase; class of enzymes that detects DNA damage and determine repair mechanism
: modifies chromatin structure for DNA repair
DBC1: deleted in breast cancer 1; regulates apoptosis, transcription and histone modifications
: usually binds to NAD+
: in the absence of NAD+, DBC1 binds to PARP1, lowering the enzyme activity of PARP1
If studies in mice hold true for humans, which of the following will be true?
a) When given NMN, NAD+ and PARP1 activity will increase.
b) When given NMN, NAD+ will increase and PARP1 activity will decrease.
c) When given NMN, NAD+ will decrease and PARP1 activity will increase.
d) When given NMN, NAD+ and PARP1 activity will decrease.
Frequently Asked Questions
What scientific concept do you need to know in order to solve this problem?
Our tutors have indicated that to solve this problem you will need to apply the DNA Repair concept. You can view video lessons to learn DNA Repair . Or if you need more DNA Repair practice, you can also practice DNA Repair practice problems.