Problem: Which of the following cells is most likely to have the greatest trouble repairing damaged DNA?a) A cell with low NAD+ and large amounts of bonded DBC1 and PARP1.b) A cell with high NAD+ and a moderate amount of bonded DBC1 and PARP1.c) A cell with low NAD+ and small amounts of bonded DBC1 and PARP1.d) A cell with large amounts of NAD+ and large amounts of bonded DBC1 and PARP1.

PARP1: poly[ADP-ribose] polymerase; class of enzymes that detects DNA damage and determine repair mechanism

: modifies chromatin structure for DNA repair

DBC1: deleted in breast cancer 1; regulates apoptosis, transcription and histone modifications

: usually binds to NAD⁺

Which of the following cells is most likely to have the greatest trouble repairing damaged DNA?

a) A cell with low NAD⁺ and large amounts of bonded DBC1 and PARP1.

b) A cell with high NAD⁺ and a moderate amount of bonded DBC1 and PARP1.

c) A cell with low NAD⁺ and small amounts of bonded DBC1 and PARP1.

d) A cell with large amounts of NAD⁺ and large amounts of bonded DBC1 and PARP1.