DNA Repair Video Lessons

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Problem: Which of the following cells is most likely to have the greatest trouble repairing damaged DNA?a) A cell with low NAD+ and large amounts of bonded DBC1 and PARP1.b) A cell with high NAD+ and a moderate amount of bonded DBC1 and PARP1.c) A cell with low NAD+ and small amounts of bonded DBC1 and PARP1.d) A cell with large amounts of NAD+ and large amounts of bonded DBC1 and PARP1.

FREE Expert Solution

PARP1: poly[ADP-ribose] polymerase; class of enzymes that detects DNA damage and determine repair mechanism

: modifies chromatin structure for DNA repair

DBC1: deleted in breast cancer 1; regulates apoptosis, transcription and histone modifications

: usually binds to NAD+

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Problem Details

Which of the following cells is most likely to have the greatest trouble repairing damaged DNA?

a) A cell with low NAD+ and large amounts of bonded DBC1 and PARP1.

b) A cell with high NAD+ and a moderate amount of bonded DBC1 and PARP1.

c) A cell with low NAD+ and small amounts of bonded DBC1 and PARP1.

d) A cell with large amounts of NAD+ and large amounts of bonded DBC1 and PARP1.

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What scientific concept do you need to know in order to solve this problem?

Our tutors have indicated that to solve this problem you will need to apply the DNA Repair concept. You can view video lessons to learn DNA Repair . Or if you need more DNA Repair practice, you can also practice DNA Repair practice problems.