PARP1: poly[ADP-ribose] polymerase; class of enzymes that detects DNA damage and determine repair mechanism
: modifies chromatin structure for DNA repair
DBC1: deleted in breast cancer 1; regulates apoptosis, transcription and histone modifications
: usually binds to NAD+
Which of the following cells is most likely to have the greatest trouble repairing damaged DNA?
a) A cell with low NAD+ and large amounts of bonded DBC1 and PARP1.
b) A cell with high NAD+ and a moderate amount of bonded DBC1 and PARP1.
c) A cell with low NAD+ and small amounts of bonded DBC1 and PARP1.
d) A cell with large amounts of NAD+ and large amounts of bonded DBC1 and PARP1.