Olanzapine is an orally-administered antipsychotic drug used to treat schizophrenia and bipolar disorder. Like most drugs (95%), Olanzapine is eliminated by first-order kinetics. The half-life for Olanzapine elimination is 36 hours.
A. Calculate the rate constant for elimination of Olanzapine. (Be sure to include units)
B. The optimal therapeutic range for Olanzapine is 20 to 40 ng/mL. Concentrations of 80 ng/mL are considered to be the upper-limit to avoid adverse side effects.
How long would it take for the concentrations of Olanzapine to drop from 80 ng/mL to 10 ng/mL?
C. By mistake, a patient was given a dose of olanzapine that resulted in a blood serum concentration of 350 ng/mL instead of the desired 35 ng/mL. Calculate how long will it take for the concentration of Olanzapine to drop from 350 ng/mL to 80 ng/mL, the fringe of the "safe zone"?
* Note estimating the amount of time based of half-life is not good enough. Calculate the time required.
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