Problem: Morphine is a weak base. A 0.150 M solution of morphine has a pH of 10.5.What is Kb for morphine?

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We are being asked to calculate the Kb for a 0.150 M solution of morphine (C17H19NO3)

Morphine (C17H19NO3) is a neutral amine, therefore we know that it is a weak base.


Since we’re dealing with a weak base and Kb is an equilibrium expression, we will have to create an ICE chart to determine the equilibrium concentration of each species:

C17H19NO3weak baseproton acceptor
H2O → will act as the weak acidproton donor


Equilibrium reaction:       C17H19NO3(aq) + H2O(l)  C17H19NO3H+(aq) + OH-(aq)

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Problem Details

Morphine is a weak base. A 0.150 M solution of morphine has a pH of 10.5.

What is Kb for morphine?

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What scientific concept do you need to know in order to solve this problem?

Our tutors have indicated that to solve this problem you will need to apply the Weak Bases concept. If you need more Weak Bases practice, you can also practice Weak Bases practice problems.

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Based on our data, we think this problem is relevant for Professor Claridge & Ramachandran's class at PURDUE.