Problem: A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate molecules bind to a protein involved in cancer. The drug molecules bind the protein in a 1:1 ratio to form a drug-protein complex. The protein concentration in aqueous solution at 25 oC is 1.72×10−6 M. Drug A is introduced into the protein solution at an initial concentration of 2.00 10-6 M. Drug B is introduced into a separate, identical protein solution at an initial concentration of 2.00 10-6 M. At equilibrium, the drug A-protein solution has an A-protein complex concentration of 1.00 10-6 M, and the drug B solution has a B-protein complex concentration of 1.40 10-6 M.Calculate the Kc value for the B-protein binding reaction.

🤓 Based on our data, we think this question is relevant for Professor Fitch's class at LUC.

FREE Expert Solution

In this problem, we are asked to calculate the equilibrium constant, Kc value for the B-Protein binding process.


When dealing with equilibrium and Kc:

Kc → equilibrium units are in molarity 
Kc is an equilibrium expression:

Kc=productsreactants

only aqueous and gaseous species are included in the equilibrium expression
▪ the coefficient of each compound in the reaction equation will be the exponent of the concentrations in the equilibrium expression 

View Complete Written Solution
Problem Details

A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate molecules bind to a protein involved in cancer. The drug molecules bind the protein in a 1:1 ratio to form a drug-protein complex. The protein concentration in aqueous solution at 25 oC is 1.72×10−6 M. Drug A is introduced into the protein solution at an initial concentration of 2.00 10-6 M. Drug B is introduced into a separate, identical protein solution at an initial concentration of 2.00 10-6 M. At equilibrium, the drug A-protein solution has an A-protein complex concentration of 1.00 10-6 M, and the drug B solution has a B-protein complex concentration of 1.40 10-6 M.

Calculate the Kc value for the B-protein binding reaction.