Ch.10 - Molecular Shapes & Valence Bond TheoryWorksheetSee all chapters
All Chapters
Ch.1 - Intro to General Chemistry
Ch.2 - Atoms & Elements
Ch.3 - Chemical Reactions
BONUS: Lab Techniques and Procedures
BONUS: Mathematical Operations and Functions
Ch.4 - Chemical Quantities & Aqueous Reactions
Ch.5 - Gases
Ch.6 - Thermochemistry
Ch.7 - Quantum Mechanics
Ch.8 - Periodic Properties of the Elements
Ch.9 - Bonding & Molecular Structure
Ch.10 - Molecular Shapes & Valence Bond Theory
Ch.11 - Liquids, Solids & Intermolecular Forces
Ch.12 - Solutions
Ch.13 - Chemical Kinetics
Ch.14 - Chemical Equilibrium
Ch.15 - Acid and Base Equilibrium
Ch.16 - Aqueous Equilibrium
Ch. 17 - Chemical Thermodynamics
Ch.18 - Electrochemistry
Ch.19 - Nuclear Chemistry
Ch.20 - Organic Chemistry
Ch.22 - Chemistry of the Nonmetals
Ch.23 - Transition Metals and Coordination Compounds

Solution: There are two compounds of the formula Pt(NH3 )2 Cl2 as shown below. The compound on the right is called cisplatin, and the compound on the left is called transplatin.One of these compounds is an anti

Problem

There are two compounds of the formula Pt(NH3 )2 Cl2 as shown below. The compound on the right is called cisplatin, and the compound on the left is called transplatin.

The first structure is a central Pt single bonded below to NH3, right to Cl, left to Cl, and above to NH3.  In the second, Pt is single bonded below and right to NH3 and left and above to Cl.

One of these compounds is an anticancer drug, and one is inactive. The anticancer drug works by its chloride ions undergoing a substitution reaction with nitrogen atoms in DNA that are close together, forming a N-Pt-N angle of about 90. Which compound would you predict to be the anticancer drug?