Hypoxia: low oxygen in the body
Which of the following regulate oxidative phosphorylation under hypoxic conditions?
A. Pyruvate dehydrogenase (PDH) kinase phosphorylates PDH, inactivating it and reducing the availability of electron carriers to the electron transport chain.
B. pH decreases below 6.5 and IF1 exists as a stable dimer capable of inhibiting the ATPase activity of ATP synthase.
C. ATP synthase converts ATP to ADP, raising [ADP] to increase the rate of oxidative phosphorylation.
D. HIF-1 replaces a subunit of Complex IV of the electron transport chain with a subunit that is more efficient under hypoxic conditions.
E. The protein inhibitor IF1 binds one ATP synthase molecule and inhibits its activity.
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