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Problem: What is the net charge at pH 7.0 on a peptide with the sequence?Ala-Thr-Leu-Asp-Ala-Lys-Pro-Glu

FREE Expert Solution

pKa Values of Amino Acids:

Amino Acid

pK1 (–COOH)

pK2 (–NH3+)

pKR (R group)

Glycine, Gly

2.34

9.60

Alanine, Ala

2.34

9.69

Proline, Pro

1.99

10.96

Valine, Val

2.32

9.62

Leucine, Leu

2.36

9.60

Isoleucine, Iso

2.36

9.68

Methionine, Met

2.28

9.31

Phenylalanine, Phe

1.83

9.13

Tyrosine, Tyr

2.20

9.11

10.07

Tryptophan, Trp

2.38

9.39

Serine, Ser

2.21

9.15

Threonine, Thr

2.11

9.62

Cysteine, Cys

1.96

10.28

8.18

Asparagine, Asn

2.02

8.80

Glutamine, Gln

2.17

9.13

Lysine, Lys

2.18

8.95

10.53

Histidine, His

1.82

9.17

6.00

Arginine, Arg

2.17

9.04

12.48

Asparate, Asp

1.88

9.60

3.65

Glutamate, Glu

2.19

9.67

4.25

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Problem Details

What is the net charge at pH 7.0 on a peptide with the sequence?

Ala-Thr-Leu-Asp-Ala-Lys-Pro-Glu

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