Antibody Structure and Diversity

Select the true statements regarding antibody (specifically, immunoglobulin G) structure.1. The heavy and light chains are linked by noncovalent and disulfide bonds.2. The antigen-binding site is formed as a combination of variable domains from one heavy and one light chain.3. Both the Fab and Fc fragments have variable domains.4. Only the Fc fragment has constant domains.5. The antigen-binding site is located in the Fab fragment.