The effect of a particular mutation, be it a substitution, deletion, or insertion, largely depends on the changes in the coding regions of DNA sequence, leading to modifications in the translated protein sequence.
A single base substitution is LEAST likely to be deleterious (dangerous) when the change results in _____.
A. the replacement of a codon specifying a hydrophilic amino acid with a codon that specifies a hydrophobic amino acid.
B. the replacement of a codon specifying an amino acid with a stop codon.
C. the substitution of an amino acid in the active site of the protein.
D. the replacement of a codon specifying an amino acid with a different codon that specifies the same amino acid.
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