The mutations caused by insertions and deletions can be formed in two ways. The insertion and deletion of longer regions can happen through homologous recombination.
Mutations due to small insertions and deletions can arise spontaneously during DNA replication because:
A. a purine in the template DNA strand mispairs with an incoming purine.
B. guanine is depurinated.
C. a purine in the template DNA strand mispairs with an incoming pyrimidine.
D. strand slippage occurs
E. a tautomeric shift takes place so that cytosine in the new DNA strand is able to pair with an adenine in the template strand.
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