Histone methylation is a known mechanism for the regulation of gene expression in eukaryotes. It is the process of adding a number of methyl groups to histone proteins of DNA and in effect tightens the DNA being wound to these histones. Histone modification leads to the switching on or off of genes.
A researcher found a method she could use to manipulate and quantify phosphorylation and methylation in embryonic cells in culture. In one set of experiments,she succeeded in decreasing methylation of histone tails. Which of the following results would she most likely see?
A. activation of histone tails for enzymatic function
B. decreased binding of transcription factors
C. increased chromatin condensation
D. inactivation of the selected genes
E. decreased chromatin condensation
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