Problem: Chargaff's results yielded a molar ratio of 1.67 for A to G in yeast DNA, 1.92 for T to C, 1.03 for A to T, and 1.20 for G to C. The ratio of purines to pyrimidines is 1.00. Calculate the mole fractions of A, G, T, and C in yeast DNA.

FREE Expert Solution

The given ratios purine-pyrimidine ratio suggests that the given DNA sample is most likely double-stranded. However, non-equal amounts of A and T, as well as G and C (i.e. their ratios are not equal to 1), suggests otherwise. Thus, we simply proceed to systems of equations.

Note that the ratio of purines to pyrimidines is 1, so A + G = T + C

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Problem Details

Chargaff's results yielded a molar ratio of 1.67 for A to G in yeast DNA, 1.92 for T to C, 1.03 for A to T, and 1.20 for G to C. The ratio of purines to pyrimidines is 1.00. Calculate the mole fractions of A, G, T, and C in yeast DNA.

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Our tutors have indicated that to solve this problem you will need to apply the Nucleic Acids concept. You can view video lessons to learn Nucleic Acids. Or if you need more Nucleic Acids practice, you can also practice Nucleic Acids practice problems.

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