The objective of DNA replication is to create a new copy of the double stranded polynucleotide strand. This follows a semi-conservative mechanism of synthesis where the parent nucleotide strand is opened up from the origin of replication, and the complementary strand is synthesized with the help of the DNA polymerase enzyme, using the primers as the starting point of base synthesis. This copying mechanism has a high degree of sequence conservation as the DNA polymerase has a proofreading and correcting function, as well.
Below is a close-up of the portion ofaDNA replication bubble found in the highlighted box. Helicase is shown as a green triangle currently moving from left to right. Based on what you know about the creation of new DNA during replication, which is the lagging strandand why?
A. A is the lagging strand, as DNA is always synthesized in the 5' to 3' manner.
B. B is the lagging strand, as DNA is always synthesized in the 5' to 3' manner.
C. A is the lagging strand, as DNA is always synthesized in the 3' to 5' manner.
D. B is the lagging strand, as DNA is always synthesized in the 3' to 5' manner.
E. It is impossible to tell, with the information provided.
Frequently Asked Questions
What scientific concept do you need to know in order to solve this problem?
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Based on our data, we think this problem is relevant for Professor Navaratnam's class at WVU.