Ch.16 - DNA SynthesisWorksheetSee all chapters
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Ch.16 - DNA Synthesis
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Solution: Below is a close-up of the portion ofaDNA replication bubble found in the highlighted box. Helicase is shown as a green triangle currently moving from left to right. Based on what you know about the creation of new DNA during replication, which is the lagging strandand why? A. A is the lagging strand, as DNA is always synthesized in the 5' to 3' manner.B. B is the lagging strand, as DNA is always synthesized in the 5' to 3' manner.C. A is the lagging strand, as DNA is always synthesized in the 3' to 5' manner.D. B is the lagging strand, as DNA is always synthesized in the 3' to 5' manner.E. It is impossible to tell, with the information provided.

Problem

Below is a close-up of the portion ofaDNA replication bubble found in the highlighted box. Helicase is shown as a green triangle currently moving from left to right. Based on what you know about the creation of new DNA during replication, which is the lagging strandand why? 

A. A is the lagging strand, as DNA is always synthesized in the 5' to 3' manner.

B. B is the lagging strand, as DNA is always synthesized in the 5' to 3' manner.

C. A is the lagging strand, as DNA is always synthesized in the 3' to 5' manner.

D. B is the lagging strand, as DNA is always synthesized in the 3' to 5' manner.

E. It is impossible to tell, with the information provided.

Solution

The objective of DNA replication is to create a new copy of the double stranded polynucleotide strand. This follows a semi-conservative mechanism of synthesis where the parent nucleotide strand is opened up from the origin of replication, and the complementary strand is synthesized with the help of the DNA polymerase enzyme, using the primers as the starting point of base synthesis. This copying mechanism has a high degree of sequence conservation as the DNA polymerase has a proofreading and correcting function, as well.

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