Problem: Cyanide blocks the transfer of electrons from cytochrome c oxidase to O2. What would be the effect of cyanide on ATP synthesis? On the Krebs cycle? Suppose there was a drug that could accept electrons from cytochrome c and transfer them directly to O2 without pumping electrons. If this drug were added together with cyanide to mitochondria, what would be the effect on the number of ATP molecules synthesized per molecule of glucose oxidized?

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The final step of ETC involves the transfer of electrons from cytochrome c to oxygen gas, O2, by way of Complex IV (also known as cytochrome oxidase). Cyanide is known to inhibit cytochrome oxidase activity, thus, the final step ofelectron transfer cannot be completed.

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Problem Details

Cyanide blocks the transfer of electrons from cytochrome c oxidase to O2. What would be the effect of cyanide on ATP synthesis? On the Krebs cycle? Suppose there was a drug that could accept electrons from cytochrome c and transfer them directly to O2 without pumping electrons. If this drug were added together with cyanide to mitochondria, what would be the effect on the number of ATP molecules synthesized per molecule of glucose oxidized?

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