Enzyme Inhibition Video Lessons

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Concept: Enzyme Inhibition

Problem: Succinate dehydrogenase catalyzes the conversion of succinate to fumarate. The reaction is inhibited by malonic acid, which resembles succinate but cannot be acted upon by succinate dehydrogenase. Increaseing the ratio of succinate to malonic acid reduces the inhibitory effect of malonic acid.Which of the following is most consistent with the information above?A. Succinate dehydrogenase is an enzyme, fumarate is a substrate, and malonic acid is an inhibitor.B. Suucinate dehydrogenase is a substrate, fumarate is a product, and malonic acid is a catalyst.C. Succinate dehydrogenase is a catalyst, succinate is a substrate, and fumarate is a product.D. Succinate dehydrogenase is an enzyme, succinate is a product, and malonic acid is a substrate.

FREE Expert Solution

An enzyme is a biological molecule that speeds up chemical reactions, whether in biological systems or in laboratory setups. They are usually proteins. Next, the substrate is the substance that is acted upon by the enzyme for its catalytic function. This is the molecule that binds to the enzyme active site and after catalysis would form the product. Inhibitors, on the other hand, prevent or reduce the efficient interaction of enzymes to their substrates that the rate of catalysis is significantly reduced or enzyme becomes inactivated altogether.

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Problem Details

Succinate dehydrogenase catalyzes the conversion of succinate to fumarate. The reaction is inhibited by malonic acid, which resembles succinate but cannot be acted upon by succinate dehydrogenase. Increaseing the ratio of succinate to malonic acid reduces the inhibitory effect of malonic acid.

Which of the following is most consistent with the information above?

A. Succinate dehydrogenase is an enzyme, fumarate is a substrate, and malonic acid is an inhibitor.

B. Suucinate dehydrogenase is a substrate, fumarate is a product, and malonic acid is a catalyst.

C. Succinate dehydrogenase is a catalyst, succinate is a substrate, and fumarate is a product.

D. Succinate dehydrogenase is an enzyme, succinate is a product, and malonic acid is a substrate.

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Based on our data, we think this problem is relevant for Professor Turnpenny's class at BU.