Problem: A ______ mutation is one that leads to premature insertion of a stop codon within an ORF.

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These mutations are classified as point mutations where a base is replaced with another. These mutations have three types, in terms of their effect on the translation product. These are the silent mutation, missense mutation, and nonsense mutation. 

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A ______ mutation is one that leads to premature insertion of a stop codon within an ORF.