Problem: The enzyme glucose-6-phosphate dehydrogenase (G6PD) deficiency is inherited as a recessive gene on the X-chromosome in humans. Below is a pedigree of a family affected by G6PD. II-2 has a child with a man that is not affected by G6PD deficiency. She is pregnant with their first child. Genetic tests that her child is a boy. What is the probability that her male child will have G6PD deficiency?A. 0B. 1/4C. 1/2D. 3/4E. 1

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FREE Expert Solution

From the given pedigree, it can be seen that the father (I-2) is G6PD deficient and the mother (I-1) is also carrier since the son (II-1) got afflicted, too. Boys only have a single X chromosome, thus, all daughters will inherit their father's X chromosome as one of theirs. This makes II-2 a definite carrier of the disorder. 

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Problem Details

The enzyme glucose-6-phosphate dehydrogenase (G6PD) deficiency is inherited as a recessive gene on the X-chromosome in humans. Below is a pedigree of a family affected by G6PD. 

II-2 has a child with a man that is not affected by G6PD deficiency. She is pregnant with their first child. Genetic tests that her child is a boy. What is the probability that her male child will have G6PD deficiency?

A. 0

B. 1/4

C. 1/2

D. 3/4

E. 1

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Based on our data, we think this problem is relevant for Professor Casteel's class at UCD.