From the given pedigree, it can be seen that the father (I-2) is G6PD deficient and the mother (I-1) is also carrier since the son (II-1) got afflicted, too. Boys only have a single X chromosome, thus, all daughters will inherit their father's X chromosome as one of theirs. This makes II-2 a definite carrier of the disorder.
The enzyme glucose-6-phosphate dehydrogenase (G6PD) deficiency is inherited as a recessive gene on the X-chromosome in humans. Below is a pedigree of a family affected by G6PD.
II-2 has a child with a man that is not affected by G6PD deficiency. She is pregnant with their first child. Genetic tests that her child is a boy. What is the probability that her male child will have G6PD deficiency?
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What scientific concept do you need to know in order to solve this problem?
Our tutors have indicated that to solve this problem you will need to apply the Sex-Linked Inheritance concept. You can view video lessons to learn Sex-Linked Inheritance. Or if you need more Sex-Linked Inheritance practice, you can also practice Sex-Linked Inheritance practice problems.
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Based on our data, we think this problem is relevant for Professor Casteel's class at UCD.