Problem: The enzyme glucose-6-phosphate dehydrogenase (G6PD) deficiency is inherited as a recessive gene on the X-chromosome in humans. Below is a pedigree of a family affected by G6PD. II-2 has a child with a man that is not affected by G6PD deficiency. She is pregnant with their first child. Genetic tests that her child is a boy. What is the probability that her male child will have G6PD deficiency?A. 0B. 1/4C. 1/2D. 3/4E. 1

FREE Expert Solution

From the given pedigree, it can be seen that the father (I-2) is G6PD deficient and the mother (I-1) is also carrier since the son (II-1) got afflicted, too. Boys only have a single X chromosome, thus, all daughters will inherit their father's X chromosome as one of theirs. This makes II-2 a definite carrier of the disorder. 

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Problem Details

The enzyme glucose-6-phosphate dehydrogenase (G6PD) deficiency is inherited as a recessive gene on the X-chromosome in humans. Below is a pedigree of a family affected by G6PD. 

II-2 has a child with a man that is not affected by G6PD deficiency. She is pregnant with their first child. Genetic tests that her child is a boy. What is the probability that her male child will have G6PD deficiency?

A. 0

B. 1/4

C. 1/2

D. 3/4

E. 1

Frequently Asked Questions

What scientific concept do you need to know in order to solve this problem?

Our tutors have indicated that to solve this problem you will need to apply the Sex-Linked Inheritance concept. You can view video lessons to learn Sex-Linked Inheritance. Or if you need more Sex-Linked Inheritance practice, you can also practice Sex-Linked Inheritance practice problems.

What professor is this problem relevant for?

Based on our data, we think this problem is relevant for Professor Casteel's class at UCD.