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Problem: Examine the pedigree below:a) What is the inheritance pattern of this disorder? Justify your answer.b) What is the probability that BOTH of the daughter IV-1 and IV-4 are carriers of the disorder?c) What is the probability that BOTH of the daughters IV-5 and IV-8 are carriers of the disorder?

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a) By elimination, the inheritance pattern for this disorder would be X-linked recessive. It is definitely not a dominant allele as they are not highly expressed even in the offspring of afflicted individuals. It is also not Y-linked as these are not inherited by all sons of afflicted fathers. It is also not autosomal recessive since a son of II-4 and II-5 became afflicted even though it is not likely for the father to be a carrier. This can only be possible if the males would only need one copy of the recessive allele for it to be expressed.

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Problem Details

Examine the pedigree below:

a) What is the inheritance pattern of this disorder? Justify your answer.

b) What is the probability that BOTH of the daughter IV-1 and IV-4 are carriers of the disorder?

c) What is the probability that BOTH of the daughters IV-5 and IV-8 are carriers of the disorder?

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Based on our data, we think this problem is relevant for Professor Sandstrom's class at UNR.