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Problem: Below is the active site of chymotrypsin. Which mutation would have a greater effect on protein function: replacing Asp102 with glutamine or glutamic acid? Why?

FREE Expert Solution

Missense mutations, such as the one given in problem, can lead to an improved protein, but it is more common for them to be neutral or detrimental. It would largely depend on the similarity of properties between the substituting amino acid (AA) and the one it replaces. 

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Problem Details

Below is the active site of chymotrypsin. Which mutation would have a greater effect on protein function: replacing Asp102 with glutamine or glutamic acid? Why?

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