Problem: Explain the role of release factors in transcription termination.

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A release factor is a protein that allows for the termination of translation by recognizing the termination codon or stop codon in an mRNA sequence. There are multiple proteins that recognizes different stop codons.

In prokaryotic transcriptional termination, there are three release factors. 

  1. RF1 recognizes the termination codons UAA and UAG
  2. RF2 recognizes UAA and UGA
  3. RF3 is a GTP-binding protein that leads to the dissociation of RF1/RF2 after peptide release
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Explain the role of release factors in transcription termination.