In a given gene, the sequence is divided into clusters that can be classified as either intron or exon. During trascription, the process known as splicing removes the introns from the transcript and the exons are connected to form a continuous sequence. Thus, insertion in both A and C will not have any noticeable effect on the protein.
A protein-coding gene is diagrammed below, with 4 exons (blue boxes) and 3 introns. A researcher has isolated four different mutant alleles of this gene, designated A, B, C, and D. Each of the alleles has a different four-basepair insertion; their locations within the gene are shown by the red triangles in the figure. Which insertion - A, B, C, or D - is likely to have the biggest effect on protein function? Explain.
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